KMID : 1146920180480030269
|
|
Journal of Pharmaceutical Investigation 2018 Volume.48 No. 3 p.269 ~ p.278
|
|
Enhancement of in vitro dissolution and pharmacodynamic potential of olanzapine using solid SNEDDS
|
|
Ahsan Mohd Neyaz
Verma Priya Ranjan Prasad
|
|
Abstract
|
|
|
The present research work focused on preparing a solidified lipidic self-nanoemulsifying drug delivery system (S-SNEDDS) by adsorbing liquid SNEDDS onto the surface of inert solid adsorbent (Aerosil-200) to improve the in vitro dissolution of poorly aqueous soluble drug, olanzapine and to evaluate their pharmacodynamic (Behavioral study) activity in Swiss albino mice. The liquid SNEDDS consisted of olanzapine, Acconon E and Cremophor EL. The powder flow properties were characterized using parameters viz. angle of repose (¥è), Haussner¡¯s ratio and Carr¡¯s index. S-SNEDDS demonstrated good flow characteristics. The solid-state characterizations of S-SNEDDS by fourier transform infrared spectroscopy, differential scanning calorimeter and powder X-ray diffraction studies confirmed the amorphous behavior of olanzapine in the S-SNEDDS. Enhanced in vitro drug release and pharmacodynamic efficacy were attained from solidified-SNEDDS in comparison to olanzapine powder signifying the immense potential offered by S-SNEDDS and it could be a better alternative for oral administration of olanzapine.
|
|
KEYWORD
|
|
Olanzapine, S-SNEDDS, Flow properties, Electron microscopy studies, Behavioral study
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|